Related Experiment Video
Updated: May 20, 2025

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Single and Double Root Translocation for Transposition and Malposition of the Great Arteries
Bari Murtuza1, Juan Lehoux1, Victor O Morell1
1Department of Pediatric Cardiovascular Surgery, St Joseph's Children's Hospital, Tampa, Florida; Department of Cardiothoracic Surgery, UPMC Medical Center & University of Pittsburgh, Pittsburgh, Pennsylvania.
Abstract:
Aortic root translocation and double root translocation have emerged as potentially valuable surgical options for complex transposition of the great arteries or double outlet right ventricle with VSD and LV outflow tract obstruction (LVOTO). These complex approaches offer excellent laminar LV outflow tracts with almost no late LVOT reinterventions. Whilst the advantages for the LVOT are clear, there is an early cost in terms of prolonged operative ischemic times compared with the Rastelli procedure or even arterial switch with LVOTO resection. This appears to translate into a degree of perioperative morbidity. Further, concerning double root translocation, a clear benefit above a single root approach with no right ventricle-pulmonary artery conduit, should be demonstrable. Adoption of root translocation should not come at the expense of a higher incidence of neo-aortic incompetence or mitral regurgitation as has been reported in some series. We suggest that the best outcomes are likely to be achieved where the strategy is tailored to individual patient anatomy and pathophysiology, particularly taking into account: the relative size of the native pulmonary-to-aortic valve; complexity of LVOTO; and presence of abnormal coronary artery patterns or associated lesions. Additional long-term data for these relatively recent techniques are still awaited, although there are some early suggestions that for the most complex reconstructions, there may be some late occurrence of heart failure. Judicious intra-operative assessment is often the final arbiter for the best approach in a given patient.
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