Central neurological symptoms as the first manifestation in Sjögren's disease

Sjögren's disease it's a heterogeneous and complex rheumatological disease, can present central neurological manifestations, with a prevalence that varies between 1-5% according to the international literature. We report a series of three cases; we present a patient who debuted with epileptic seizures, one with catatonic syndrome and a last one with optic neuritis. Knowing the various presentations of the central neurological manifestations allows us to broaden the diagnostic suspicion from the beginning, providing timely treatment.