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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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Functional divergence between the two cerebral hemispheres contributes to human fluid intelligence.

Xinyu Liang1,2, Junhao Luo3,4,5, Qiuhui Bi6

  • 1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. xinyu_liang@fudan.edu.cn.

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Greater brain hemisphere divergence, particularly in the frontoparietal network, is linked to higher fluid intelligence. This study quantifies the relationship between brain lateralization and cognitive abilities.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Human Intelligence Research

Background:

  • Hemispheric lateralization is theorized to confer cognitive advantages and drive human intelligence.
  • Quantitative links between the degree of brain lateralization and human intelligence remain underexplored.

Purpose of the Study:

  • To propose and apply a novel framework for quantifying between-hemisphere functional divergence.
  • To investigate the association between hemispheric functional divergence and fluid intelligence.

Main Methods:

  • Developed a framework using functional aligned multidimensional representation space from hemispheric functional gradients.
  • Computed between-hemisphere distances within this space.
  • Applied the framework to a large cohort (N=777).

Main Results:

  • Identified significant functional divergence across hemispheres in the frontoparietal network.
  • Found positive associations between global and regional divergence (within the multiple demand network) and fluid composite scores.
  • Demonstrated that divergence partially mediated the relationship between brain size and fluid intelligence.

Conclusions:

  • Hemispheric lateralization is a fundamental organizational principle of the human brain.
  • Empirical evidence supports the role of hemispheric functional divergence in supporting fluid intelligence.
  • The proposed framework offers a quantitative approach to study brain lateralization and cognition.