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The Relationship of Chronic Inflammation in Prostate Biopsies with International Society of Urological Pathology
Hakan Polat1, Ubeyd Sungur2, Mithat Ekşi2
1Department of Urology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, drhakanpolat@gmail.com.
Introduction:
This study aimed to investigate the relationship between the International Society of Urological Pathology (ISUP) score upgrade and inflammation in transrectal ultrasound-guided prostate biopsy (TRUS-Bx) specimens.
Methods:
The data of 340 patients who underwent robot-assisted radical prostatectomy were retrospectively evaluated, and two groups were formed based on the presence (Group 1, n = 168) or absence (Group 2, n = 172) of an ISUP score upgrade. Prostate characteristics, imaging findings, and inflammation on TRUS-Bx were recorded in both groups for statistical analysis. Univariate and multivariate analyses were used to identify factors predicting the development of the upgrade.
Results:
Total inflammation was significantly greater in Group 1 compared to Group 2 (p = 0.04). Glandular-located inflammation was significantly higher in Group 2 compared to Group 1 (p = 0.001). When the factors predicting ISUP score upgrade were examined, glandular inflammation was found to be significant in univariate analysis (p = 0.001), while seminal vesicle invasion in multiparametric magnetic resonance imaging and ISUP grade in TRUS-Bx were found to be significant predictors in multivariate analysis (p = 0.022, p = 0.009, respectively).
Conclusion:
Prostatitis accompanying prostate cancer is observed more frequently in patients with an ISUP score upgrade. The location of inflammation may offer insights into predicting an upgrade.
