Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Kidney Structure01:45

Kidney Structure

69.3K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.3K
Renal Corpuscle01:20

Renal Corpuscle

1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K
Disorders of the Urinary System01:20

Disorders of the Urinary System

266
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
266
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

864
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
864
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

1.4K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in chronic dialysis practices and outcomes in North American children: a 30-year NAPRTCS registry analysis.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Contemporary Treatment Responses of Recurrent Focal Segmental Glomerulosclerosis or Steroid Resistant Nephrotic Syndrome in Children after Kidney Transplantation: Phase 2 of a Multicenter Electronic Health Record Data Analysis.

Research square·2026
Same author

Identification of monogenic variants in steroid-resistant and steroid-sensitive nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Trio exome sequencing identifies de novo variants in novel candidate genes in 19.62% of CAKUT families.

Genetics in medicine : official journal of the American College of Medical Genetics·2025
Same author

Reaching for Individualized Medicine in Diabetic Kidney Disease.

JAMA network open·2025
Same author

Global access to management of primary hyperoxaluria: a survey on behalf of OxalEurope, G&K Working Group of the ERA and ESPN.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2025
Same journal

Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

High Protein Diets: What to Tell Our Patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K

Understanding Rare Kidney Stone Diseases: A Review.

Michelle A Baum1, Mallory Mandel1, Michael J G Somers1

  • 1Division of Nephrology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|May 18, 2025
PubMed
Summary
This summary is machine-generated.

Rare kidney stone diseases, including nephrolithiasis and nephrocalcinosis, often appear in youth. Genetic testing aids diagnosis, enabling early treatment to preserve kidney function.

Keywords:
Rare Kidney Stone Diseases, Genetic Kidney Stone Diseases, Nephrolithiasis, Nephrocalcinosis, Primary hyperoxaluria, cystinuria, Dent disease

More Related Videos

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.0K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

525

Related Experiment Videos

Last Updated: Jun 15, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K
Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.0K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

525

Area of Science:

  • Nephrology
  • Medical Genetics
  • Pediatric Nephrology

Background:

  • Rare kidney stone diseases (nephrolithiasis/nephrocalcinosis) commonly manifest in childhood or adolescence.
  • These conditions can lead to significant kidney injury and potential kidney failure.
  • Early diagnosis and intervention are crucial for managing these rare diseases.

Purpose of the Study:

  • To highlight the importance of genetic testing in diagnosing hereditary kidney stone diseases.
  • To emphasize the need for early detection and tailored therapies in managing rare kidney stone disorders.
  • To inform nephrologists and urologists about monogenic rare kidney stone diseases, their diagnosis, and management.

Main Methods:

  • Review of clinical presentation and diagnostic approaches for rare kidney stone diseases.
  • Emphasis on the role of screening blood and urine tests.
  • Discussion on the utility of genetic testing in identifying hereditary stone conditions.

Main Results:

  • Genetic testing is increasingly accessible and cost-effective for diagnosing inherited stone conditions.
  • Specific clinical indicators suggest a higher likelihood of inherited kidney stone disease.
  • Early detection facilitates tailored therapies that can positively impact disease progression.

Conclusions:

  • Genetic testing is a valuable tool for diagnosing rare kidney stone diseases, especially with suggestive family or clinical history.
  • Prompt diagnosis allows for initiating treatments that can preserve kidney function and prevent severe complications.
  • Healthcare providers must possess a foundational understanding of these monogenic disorders for optimal patient care.