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Updated: May 10, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
Multi-active-site antibacterial modification of dopamine-hyaluronic acid hydrogel with N-halamine for skin tissue
Chenghao Li1, Saren Gerile2, Nan Du2
1Sinopec Research Institute of Petroleum Processing Co., Ltd., Beijing 100083, China.
Abstract:
Antibacterial hydrogels have attracted much attention in skin tissue engineering due to their superior ability to prevent infection. In this study, we developed an antibacterial hydrogel using a multi-active site N-halamine-modified dopamine-hyaluronic acid hydrogel. The in vitro antibacterial efficacy of the hydrogel exhibited 99.99 % against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, while also demonstrating excellent biocompatibility. Furthermore, in Escherichia coli-infected skin wounds, the hydrogels effectively suppressed infection and significantly accelerated wound healing. These findings suggest that N-halamine-modified dopamine-hyaluronic acid antibacterial hydrogels have great potential as wound dressings for preventing infection and promoting the healing of infected wounds.
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