Related Experiment Video

Updated: Jun 25, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K

Advancing cardiac resynchronization therapy techniques: evaluating safety, efficacy, and long-term outcomes with

Burcu Kodal1, Aziz Inan Celik1, Tahir Bezgin1

  • 1Department of Cardiology, Gebze Fatih State Hospital, Kocaeli, Turkey.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|May 18, 2025
PubMed

Insights

Percutaneous coronary venoplasty (PCV) and balloon capping improve left ventricular lead placement in cardiac resynchronization therapy (CRT) for challenging anatomies, enhancing ejection fraction.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is vital for heart failure patients with wide QRS.
  • Optimal left ventricular (LV) lead placement is critical but often hindered by complex coronary venous anatomy.
  • This study investigates novel techniques to address these anatomical challenges.

Purpose of the Study:

  • To evaluate the safety, efficacy, and long-term outcomes of percutaneous coronary venoplasty (PCV) for LV lead implantation.
  • To assess a novel "balloon capping" technique for navigating tortuous coronary veins.
  • To compare outcomes between PCV-assisted and conventional CRT implantation.

Main Methods:

  • Retrospective analysis of 44 CRT patients, divided into PCV-assisted (n=15) and conventional (n=29) groups.
  • Utilized a "balloon capping" technique in select cases with tortuous venous pathways.
  • Compared baseline characteristics, procedural success, and clinical outcomes (EF, QRS duration, NYHA class) using Kaplan-Meier and Cox regression analyses.

Main Results:

  • PCV achieved successful LV lead placement in all cases, even in smaller vessels (p<0.001).
  • The PCV group showed significantly greater improvement in ejection fraction (ΔEF, p=0.030), indicating better CRT response.
  • Balloon capping (11.4% of cases) yielded comparable success and outcomes; no significant differences in mortality or hospitalizations were observed between groups.

Conclusions:

  • PCV facilitates successful LV lead placement in anatomically challenging cases, leading to significant improvements in ejection fraction.
  • The "balloon capping" technique is a viable option for difficult venous anatomies.
  • Larger studies are warranted to confirm these findings and explore long-term clinical implications.
Abstract

Keywords:
Balloon cappingCardiac resynchronization therapyCoronary venoplastyHeart failure

More Related Videos

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

1.8K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

328

Related Concept Videos

Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...