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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Updated: May 20, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Clonal Hematopoiesis and Solid Cancers.

Yen T M Nguyen1, Manabu Fujisawa2,3, Shumpei Ishikawa4,5

  • 1Department of Hematology, University of Tsukuba Hospital, University of Tsukuba, Tsukuba, Japan.

Cancer Science
|May 19, 2025
PubMed
Summary
This summary is machine-generated.

Clonal hematopoiesis, stem cell mutations in aging, is linked to solid cancers. These mutations can drive cancer progression and impact treatment, offering new therapeutic targets.

Keywords:
TET2 mutationsT‐cell lymphomasagingclonal hematopoiesissolid cancerstumor microenvironments

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Clonal hematopoiesis (CH) involves hematopoietic stem cell expansion with mutations, prevalent in aging.
  • CH-associated mutations (DNMT3A, TET2, ASXL1, TP53) are increasingly linked to solid cancers.

Purpose of the Study:

  • Review the relationship between CH and solid cancers.
  • Discuss risk factors, impact on tumor microenvironment, and clinical implications.

Main Methods:

  • Literature review focusing on CH and solid cancer co-occurrence.
  • Analysis of mutation prevalence, risk factors, and pathogenetic mechanisms.

Main Results:

  • CH mutations influence tumorigenesis and shape the tumor microenvironment (immunoregulation, inflammation, angiogenesis).
  • CH acts as both a cancer risk marker and a driver of solid cancer progression.

Conclusions:

  • CH has significant prognostic value and affects treatment response in solid cancers.
  • CH presents potential therapeutic targets for cancer management.