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Recent advances in 3D models for multiparametric blood-brain barrier detection in microfluidic systems
Chiara Boncristiani1, Alessia Di Gilio2, Federica De Castro3
1Department of Experimental Medicine, University of Salento c/o College Isufi, Centro Ecoteckne, Via Monteroni 73100, Lecce, Italy. viviana.vergaro@unisalento.it.
Journal of Materials Chemistry. B
|May 19, 2025
Summary
Microfluidic devices accurately model the blood-brain barrier (BBB), advancing neuroscience and pharmaceutical research. Integrating chemical sensors offers new diagnostic tools and therapeutic insights for brain vascular conditions.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- The blood-brain barrier (BBB) is crucial for brain function and disease.
- Traditional models (2D, Transwell) have limitations in mimicking the BBB's complexity.
- Microfluidics offers advanced solutions for BBB research.
Purpose of the Study:
- To review recent advances in microfluidic BBB models.
- To explore the integration of chemical sensors for BBB evaluation.
- To discuss future prospects for microfluidic BBB systems in research and therapy.
Main Methods:
- Review of microfluidic technologies for BBB modeling.
- Discussion of sensor integration (electrochemical, MIPs, metabolomic).
- Analysis of current challenges and future opportunities.
Main Results:
- Microfluidic BBB models accurately mimic physiological characteristics.
- Sensor integration provides insights into metabolites and BBB function.
- These advancements aid in developing therapies and diagnostics.
Conclusions:
- Microfluidic BBB models are superior to traditional methods.
- Chemical sensor integration enhances BBB evaluation capabilities.
- Future research holds promise for multi-disciplinary applications and disease treatments.
