Interconnections of Multimorbidity-Related Clinical Outcomes: Analysis of Health Administrative Claims Data With a...

Given the rising complexity and burden of multimorbidity, it is crucial to provide evidence-based support for managing multimorbidity-related clinical outcomes. This study introduces a dynamic network approach to investigate conditional and time-varying interconnections in disease-specific clinical outcomes. Our method effectively tackles the issue of zero inflation, a frequent challenge in medical data that complicates traditional modeling techniques. The theoretical foundations of the proposed approach are rigorously developed and validated through extensive simulations. Using Taiwan's health administrative claims data from 2000 to 2013, we construct 14 yearly networks that are temporally correlated, featuring 125 nodes that represent different disease conditions. Key network properties, such as connectivity, module, and temporal variation are analyzed. To demonstrate how these networks can inform multimorbidity management, we focus on breast cancer and analyze the relevant network structures. The findings provide valuable clinical insights that enhance the current understanding of multimorbidity. The proposed methods offer promising applications in shaping treatment strategies, optimizing health resource allocation, and informing health policy development in the context of multimorbidity management.