Nanomaterial-modified electrochemical aptasensors for tetracycline detection: a review

Excessive residues of tetracyclines in the livestock, food products and environment can lead to their accumulation in the human body through the food chain, unavoidably posing a threat to the human health. Therefore, it is essential to establish detection methods with high specificity, stability, and sensitivity. Among the numerous detecting techniques, electrochemical sensors with aptamers working as biorecognition elements have been increasingly applied to monitor tetracyclines. Notably, the synergy of a wide range of nanomaterials with aptamer-based sensors has improved the charge transfer efficiency and signal sensitivity. In this review, the advantages of aptamer-based recognition methods are discussed, and the measuring processes of electrochemical detection are introduced. Then, advances in electrochemical aptasensors used for detecting tetracyclines are summarized with an emphasis on the role of nanomaterials, such as carbon-based nanomaterials and gold-based nanomaterials, functioning as -transducing media and electrically conductive polymers. Finally, the current challenges and emerging trends in this field are also discussed, shedding light on the prospects for developing new aptasensors for tetracycline detection.