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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Catch Up with the Latest Trend in Vascular Intervention-Chronic Limb-threatening Ischemia Up to Date
1Department of Cardiovascular Surgery, JA Hiroshima General Hospital, Japan.
Insights
Endovascular treatment shows promise for lower extremity artery disease, but outcomes for chronic limb-threatening ischemia require further investigation due to complex lesion characteristics.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Interventions
Background:
- Endovascular treatment is widely used for lower extremity artery disease, with proven durability for intermittent claudication.
- Clinical outcomes for endovascular treatment in chronic limb-threatening ischemia (CLTI) are less understood.
- CLTI cases often present complex lesions (small vessels, calcification, CTOs, poor runoff) leading to poorer results.
Purpose of the Study:
- To review existing guidelines and reports on endovascular treatment for lower extremity artery disease.
- To highlight the challenges and current understanding of endovascular treatment in CLTI.
- To provide an overview of the current landscape of endovascular interventions for CLTI.
Main Methods:
- Literature review of previous guidelines and clinical reports.
- Analysis of studies focusing on endovascular treatment for lower extremity artery disease.
- Synthesis of data concerning outcomes in patients with intermittent claudication versus CLTI.
Main Results:
- Endovascular treatment is increasingly recommended for intermittent claudication.
- Data on the efficacy and durability of endovascular treatment for CLTI remains limited.
- Complex lesion characteristics in CLTI contribute to treatment challenges and suboptimal outcomes.
Conclusions:
- While endovascular treatment is effective for intermittent claudication, its application in CLTI necessitates further research.
- Addressing complex lesions in CLTI remains a significant challenge for endovascular therapies.
- The review underscores the need for continued investigation into optimizing endovascular strategies for CLTI.
Abstract:
Endovascular treatment for patients with lower extremity artery disease is conducted worldwide due to its efficacy. Many studies have shown durability for patients with intermittent claudication, and various guidelines have shifted to the use of endovascular treatment. However, clinical outcomes in patients with chronic limb-threatening ischemia who undergo endovascular treatment have not been fully investigated. Generally, chronic limb-threatening ischemia cases have complex lesions such as small vessels, severe calcification, poor runoff vessels, chronic total occlusion, and long lesions, which result in poor outcomes. Thus, endovascular treatment for chronic limb-threatening ischemia cases remains challenging, despite the many technical and device advances. In 2019, the Global Vascular Guidelines were proposed for the treatment of patients with chronic limb-threatening ischemia. Here, we review previous guidelines and reports of patients with lower extremity artery disease who underwent endovascular treatment.
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