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Updated: May 21, 2025

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons
Published on: June 8, 2014
Implications of Krüppel-like factor signaling in neuroinflammation for neurodegenerative diseases
Sarah Velez1, Ebaa Ababneh1, Kiminobu Sugaya1
1Burnett School of Biomedical Sciences, University of Central Florida College of Medicine Orlando, FL 32827, USA.
Abstract:
Neurodegenerative diseases (NDs) pose a formidable challenge in modern healthcare and are characterized by progressive neuronal dysfunction and loss. Emerging research underscores the intricate interplay between neuroinflammation and mechanisms underlying ND pathogenesis. This review delves into the complex role of Krüppel-like factors (KLFs) in the context of neuroinflammation and major NDs. KLFs exert diverse effects in the brain on cellular processes such as blood-brain barrier integrity, neuronal cell cycle progression, and glial cell activation. Modulation of KLF expression and signaling emerges as a promising strategy to mitigate ND progression. By elucidating KLFs' multifaceted implications across diverse pathways and cellular processes implicated in ND progression, this review offers valuable insights into their therapeutic potential as targets for NDs.
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