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Association between serum response factor, microvascular density, and postoperative recurrence in glioma patients

  • 0Department of Neurosurgery, The Second Affiliated Hospital of Air Force Medical University Xi'an 710000, Shaanxi, China.
American Journal of Translational Research +

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May 19, 2025

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May 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Serum response factor (SRF) and microvessel density (MVD) are elevated in high-grade glioma and correlate with recurrence. SRF and MVD show potential as biomarkers for predicting glioma progression and postoperative recurrence.

Area Of Science

  • Neuro-oncology
  • Molecular Biology
  • Biomarker Discovery

Background

  • Glioma is a primary brain tumor with significant morbidity.
  • Identifying reliable biomarkers for glioma progression and recurrence is crucial for patient management.
  • Serum response factor (SRF) and microvessel density (MVD) are implicated in tumor biology.

Purpose Of The Study

  • To investigate serum response factor (SRF) expression in glioma patients.
  • To assess the association between SRF, microvessel density (MVD), and postoperative recurrence.
  • To evaluate the diagnostic and predictive potential of SRF and MVD for glioma progression and recurrence.

Main Methods

  • Retrospective analysis of 100 glioma patients.
  • Measurement of serum SRF levels and assessment of MVD in tumor specimens.
  • Correlation and regression analyses to determine associations between SRF, MVD, and clinical outcomes.
  • Receiver operating characteristic (ROC) curve analysis for diagnostic and predictive accuracy.

Main Results

  • SRF and MVD levels were significantly higher in high-grade gliomas compared to low-grade gliomas.
  • Combined SRF and MVD demonstrated improved diagnostic AUC (0.760) for glioma progression compared to individual markers.
  • SRF and MVD were positively correlated with lymph node metastasis and each other.
  • Elevated SRF and MVD levels were associated with increased risk of postoperative recurrence, with combined AUC of 0.782 for prediction.

Conclusions

  • Serum response factor (SRF) is upregulated in high-grade glioma and positively correlates with MVD.
  • SRF and MVD are significantly associated with glioma recurrence.
  • SRF may serve as a valuable biomarker for predicting glioma progression and postoperative recurrence.

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