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[Sensitivity of the wound microflora of oncological patients to some new antibiotics]
Abstract:
Sensitivity of the microflora of the oncological patients' wounds to the new antibiotics, such as gentamicin, kanamycin, oxacillin, ampicillin and lincomycin was studied with the help of the disc method. The discs with the above antibiotics were prepared under laboratory conditions in accordance with the respective instructions in the WHO. Sensitivity of 429 bacterial cultures, including 98 cultures of pathogenic staphylocci, 45 cultures of Enterococci, 43 hemolytic streptococci, 143 cultures of Escherichia, 50 cultures of Ps. aeruginosa and 50 cultures of Proteus was determined. The studies showed that gentamicin was the most active antibiotic aganist all the microbial species isolated from the surgical and other wounds of oncological patients. It may be used in treatment of the infections caused by association of the microbes belonging to different species, as well as in treatment of purulent processes before elucidating their etiology, 16.7 per cent of the Enterococcal isolates were resistant to gentamicin. Monomycin, kanamycin, oxacillin, lincomycin and macrolide antibiotics at present are sufficiently active against pathogenic staphylococci and hemolytic streptococci.
Insights
Gentamicin demonstrated the highest effectiveness against wound microflora in oncological patients. This antibiotic is suitable for treating mixed bacterial infections and purulent processes before diagnosis.
Area of Science:
- Microbiology
- Oncology
- Infectious Diseases
Background:
- Wound infections are a significant concern in oncological patients.
- Understanding antibiotic sensitivity is crucial for effective treatment.
- Emerging antibiotic resistance necessitates evaluation of new antimicrobial agents.
Purpose of the Study:
- To assess the sensitivity of wound microflora from oncological patients to several new antibiotics.
- To identify the most effective antibiotic for treating infections in this patient group.
Main Methods:
- Laboratory testing of antibiotic sensitivity using the disc diffusion method.
- Evaluation of 429 bacterial cultures, including Staphylococcus, Enterococcus, Streptococcus, Escherichia, Pseudomonas aeruginosa, and Proteus species.
- Preparation of antibiotic discs according to WHO guidelines.
Main Results:
- Gentamicin exhibited the highest activity against all tested microbial species isolated from oncological patient wounds.
- While generally effective, 16.7% of Enterococcal isolates showed resistance to gentamicin.
- Monomycin, kanamycin, oxacillin, lincomycin, and macrolides were found to be sufficiently active against pathogenic staphylococci and hemolytic streptococci.
Conclusions:
- Gentamicin is a highly effective antibiotic for treating polymicrobial infections and empirical treatment of purulent processes in oncological patients.
- Monitoring gentamicin resistance, particularly in Enterococci, is important.
- Other tested antibiotics show varying degrees of efficacy against specific pathogens.