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Related Experiment Video

Updated: Jun 25, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

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Computational Fluid Dynamics Based Risk-Stratification of Modified Blalock-Taussig-Thomas Shunt Thrombogenicity.

Yi Qiao, Ethan Penn, Jacob Miller

Medrxiv : the Preprint Server for Health Sciences

|May 19, 2025

Summary

Optimizing modified Blalock-Taussig-Thomas shunt (mBTTS) geometry, specifically shunt angle and placement, can reduce thrombosis risk. This computational study offers guidance for surgical planning to improve outcomes in infants with single-ventricle physiology.

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In Vitro Thrombosis Test for Ventricular Assist Devices

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Area of Science:

Cardiovascular Surgery
Pediatric Cardiology
Biomedical Engineering

Background:

The modified Blalock-Taussig-Thomas shunt (mBTTS) is crucial for single-ventricle physiology but faces 8-12% thrombosis-related occlusion.
Existing antithrombotic strategies do not address hemodynamic factors driving mBTTS thrombosis.
Understanding shunt flow dynamics is vital for preventing failure.

Purpose of the Study:

To determine how mBTTS geometry influences hemodynamics and thrombosis risk.
To provide quantitative guidance for optimizing surgical planning and shunt design.

Main Methods:

Constructed 54 idealized mBTTS configurations using patient-specific imaging data.
Systematically varied pulmonary artery diameter, shunt diameter, and insertion angle.
Employed computational fluid dynamics to analyze wall shear rate (WSR), elongational strain rate (ESR), and turbulence intensity (TI).

Main Results:

Identified optimal geometric configurations through computational analysis.
Peak WSR and ESR occurred at bifurcations; peak TI was in the shunt channel.
A 60° insertion angle, 4.0mm shunt graft, and distal placement to the right carotid artery showed favorable hemodynamics for clot prevention.

Conclusions:

Developed a framework for optimizing mBTTS design based on hemodynamic risk factors.
Provided actionable recommendations for shunt placement and design to reduce thrombosis.
Established a foundation for hemodynamically guided interventions to improve survival in high-risk pediatric patients.