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Updated: May 21, 2025
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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Published on: August 23, 2024
300
Nanoemulsions Based Therapeutic Strategies: Enhancing Targeted Drug Delivery against Breast Cancer Cells
Zahra Izadiyan1, Thomas J Webster2,3,4, Pooneh Kia5
1Department of Chemistry, Universiti Malaya, Kuala Lumpur, Malaysia.
International Journal of Nanomedicine
|May 19, 2025
Summary
Nanoemulsions (NEs) offer advanced breast cancer treatment by improving drug delivery and overcoming resistance. These nanoscale systems enhance targeted therapy, reduce toxicity, and hold promise for revolutionizing oncology care.
Area of Science:
- Oncology
- Nanotechnology
- Materials Science
Background:
- Conventional breast cancer treatments face limitations like systemic toxicity, poor bioavailability, and multidrug resistance.
- Nanoemulsions (NEs) are colloidal systems with nanoscale droplets (~100 nm) offering high surface area-to-volume ratio and tunable properties.
- NEs present a promising alternative for targeted drug delivery in oncology, particularly for breast cancer therapy.
Purpose of the Study:
- To comprehensively review nanoemulsion formulation techniques and stability optimization for breast cancer therapy.
- To analyze the role of NEs in modulating tumor microenvironments and enhancing therapeutic efficacy.
- To highlight advancements in NE-driven drug accumulation, reduced relapse rates, and combination therapies for precision breast cancer treatment.
Main Methods:
- Analysis of NE formulation techniques including ultrasonication, phase inversion temperature, and bubble bursting.
- Review of methods for stability optimization using surfactant dynamics.
- Examination of predictive modeling for nanoemulsion droplet behavior.
Main Results:
- NEs enable precise tumor targeting through passive (EPR effect) and active (ligand-functionalized surfaces) mechanisms, reducing off-target effects.
- NEs improve solubility and controlled release of hydrophobic drugs, enhancing efficacy against resistant breast cancer subtypes (e.g., triple-negative, HER2-positive).
- NEs demonstrate potential in preclinical models for modulating tumor microenvironments, inducing apoptosis, and inhibiting angiogenesis.
Conclusions:
- Nanoemulsions show significant potential to revolutionize breast cancer treatment by improving drug delivery, overcoming resistance, and reducing side effects.
- Further research is needed for clinical translation, scalability, and development of multifunctional NE designs for precision oncology.
- NEs offer a transformative approach to address unmet needs in advanced breast cancer therapy.
