A Selenium Disulfide-Based Shampoo Is Beneficial for Dandruff Management and Rebalancing the Scalp Microbiome of...

Dandruff is a chronic scalp condition occurring in all hair types. Selenium disulfide (SeS₂) shampoo is beneficial in dandruff and rebalances the scalp microbiome. However, data regarding subjects with curly hair are missing. This study assessed the clinical and scalp microbiome benefits of SeS₂ shampoo in subjects of any hair type with moderate-to-severe dandruff.

A 6-week study in adult subjects of any De La Mettrie hair type (I-VIII) assessed total dandruff, SD severity score (SSSD), erythema, hair greasiness, quality of life, discomfort, local tolerance, perceived benefit, acceptability, cosmeticity, and changes in the scalp microbiota. SeS₂ shampoo was applied twice every week.

Overall, 93 subjects of any hair type (women: 83%, hair types: I-III: 41%, IV-V: 29%, VI-VIII: 30%) were recruited. 69% were of European and 31% of African origin. SSSD and total dandruff scores were the highest in hair type IV-V, erythema scores in hair type I-III, and the itching score in hair type VI-VIII, with no differences between hair types for any parameter. After 4 weeks, clinical signs and subject assessments had significantly (all p < 0.05) decreased in all phototypes. SeS₂ shampoo significantly (p < 0.001) rebalanced the scalp microbiome. All subjects highly appreciated its benefit, acceptability, and cosmeticity. SeS₂ shampoo was well tolerated.

SeS₂ shampoo is beneficial in moderate-to-severe dandruff and rebalances the scalp microbiota in all hair types. SeS₂ shampoo was highly appreciated by the subjects for its benefit, acceptability, and cosmeticity, allowing a potential improvement of compliance, including in the long term.