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Stem cell therapies in the clinic
Shrinivas Acharya1,2, Suyog Shaha1,2, Michael Griffith Bibbey1,2
1John A. Paulson School of Engineering and Applied Sciences Harvard University Massachusetts USA.
Bioengineering & Translational Medicine
|May 19, 2025
Summary
Stem cell therapies offer a promising medical advancement for various diseases, utilizing living cells for complex biological functions. This review analyzes approved stem cell products and ongoing clinical trials, focusing on hematopoietic and mesenchymal stem cells.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Cellular Therapeutics
Background:
- Stem cell therapies represent a paradigm shift in medicine, offering potential cures for diverse diseases.
- Unlike traditional drugs, stem cells perform complex biological functions, expanding therapeutic possibilities.
- Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the most extensively researched types.
Purpose of the Study:
- To provide a comprehensive analysis of the current clinical landscape of stem cell therapies.
- To review regulatory-approved stem cell products and ongoing clinical trials.
- To identify key challenges hindering the clinical translation of stem cell therapies.
Main Methods:
- Systematic review of regulatory-approved stem cell products.
- Analysis of data from approximately 800 ongoing clinical trials.
- Focus on hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs).
Main Results:
- 27 stem cell products have received regulatory approval.
- Over 800 clinical trials are currently investigating stem cell therapies.
- Significant ongoing research in HSC and MSC applications.
Conclusions:
- Stem cell therapies demonstrate substantial clinical progress with numerous approved products and trials.
- Hematopoietic and mesenchymal stem cells are central to current therapeutic development.
- Addressing specific challenges is crucial for advancing stem cell therapy translation.
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