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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: May 21, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
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In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

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Stem cell therapies in the clinic.

Shrinivas Acharya1,2, Suyog Shaha1,2, Michael Griffith Bibbey1,2

  • 1John A. Paulson School of Engineering and Applied Sciences Harvard University Massachusetts USA.

Bioengineering & Translational Medicine
|May 19, 2025
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Summary

Stem cell therapies offer a promising medical advancement for various diseases, utilizing living cells for complex biological functions. This review analyzes approved stem cell products and ongoing clinical trials, focusing on hematopoietic and mesenchymal stem cells.

Keywords:
HSCMSCcellcell therapyclinical translationclinical trialsiPSCstem cell

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Cellular Therapeutics

Background:

  • Stem cell therapies represent a paradigm shift in medicine, offering potential cures for diverse diseases.
  • Unlike traditional drugs, stem cells perform complex biological functions, expanding therapeutic possibilities.
  • Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the most extensively researched types.

Purpose of the Study:

  • To provide a comprehensive analysis of the current clinical landscape of stem cell therapies.
  • To review regulatory-approved stem cell products and ongoing clinical trials.
  • To identify key challenges hindering the clinical translation of stem cell therapies.

Main Methods:

  • Systematic review of regulatory-approved stem cell products.
  • Analysis of data from approximately 800 ongoing clinical trials.
  • Focus on hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs).

Main Results:

  • 27 stem cell products have received regulatory approval.
  • Over 800 clinical trials are currently investigating stem cell therapies.
  • Significant ongoing research in HSC and MSC applications.

Conclusions:

  • Stem cell therapies demonstrate substantial clinical progress with numerous approved products and trials.
  • Hematopoietic and mesenchymal stem cells are central to current therapeutic development.
  • Addressing specific challenges is crucial for advancing stem cell therapy translation.