Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sex-linked Disorders

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

Pedigree Analysis

Pedigree Analysis

X-linked Traits

X-linked Traits

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Extrinsic and Intrinsic Pathways of Hemostasis

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Uncommon Occipital Horn Arachnoid Cyst in a Newborn.

Cureus·2026

Same author

Circadian clocka regulates the zebrafish central neuronal Mauthner-cell axon regeneration via phosphodiesterase family pde4a.

NPJ Regenerative medicine·2026

Same author

A spatial in situ hybridization approach to T cell clonotype analysis using T cell receptor variable gene probes.

Cell reports·2026

Same author

Imaging features of pancreatic ectopic thyroid tissue.

Diagnostic and interventional imaging·2026

Same author

Integrative multi-omics and network perturbation analysis in human airway organoids reveals product-specific toxicity profiles of heated tobacco products.

Ecotoxicology and environmental safety·2026

Same author

From biomarkers to the risk index: a novel integrated model using multidimensional urinary biomarkers to quantify e-cigarette exposure.

Archives of toxicology·2026

Search research articles

Related Experiment Video

Updated: May 21, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

A Family With Factor VII Deficiency: A Possible Autosomal Dominant Transmission.

Zheng Song¹, Stephenie Garcia¹, Thiagarajan Nandhagopal²

¹Family Medicine, Rio Bravo Family Medicine Residency Program, Bakersfield, USA.

|May 19, 2025

Summary

A rare factor VII deficiency caused severe anemia and heavy menstrual bleeding in an 11-year-old girl. Treatment with recombinant factor VII was successful, and family screening suggested a dominant inheritance pattern.

Keywords:

autosomal dominant inheritance coagulation disorder factor vii deficiency genetic transmission hereditary bleeding disorder

More Related Videos

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

Related Experiment Videos

Last Updated: May 21, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

Area of Science:

Hematology
Genetics
Pediatrics

Background:

Coagulation factor VII is vital for the extrinsic pathway of hemostasis.
Factor VII deficiency is a rare cause of abnormal uterine bleeding (AUB).

Observation:

An 11-year-old girl presented with prolonged heavy menstrual bleeding and hemodynamic instability.
Initial labs showed prolonged PT/INR with normal PTT, indicating a potential coagulation factor issue.

Findings:

Severe factor VII deficiency was confirmed by activity assay.
The patient's bleeding was effectively managed using recombinant human factor VII.
Family screening indicated reduced factor VII activity in maternal relatives, suggesting possible dominant inheritance.

Implications:

Highlights factor VII deficiency as a critical differential diagnosis for AUB in adolescents.
Demonstrates the efficacy of recombinant factor VII in managing acute bleeding episodes.
Underscores the need for genetic testing to confirm inheritance patterns in coagulation disorders.