Diffuse Large B-Cell Lymphoma Presenting With Multiple Episodes of Acute Pancreatitis

Gallstones and alcohol use are the most common causes of acute pancreatitis. When these etiologies are effectively ruled out, some less frequent causes include hypertriglyceridemia, medications, autoimmune conditions, and malignancy. Although rare, lymphoma infiltrating the pancreas can present with episodes of acute pancreatitis. In this report, we discuss a rare case of a patient who presented with multiple episodes of acute pancreatitis due to diffuse large B-cell lymphoma (DLBCL) infiltrating the pancreas. In the process, we emphasize the importance of maintaining a broad differential and performing the appropriate diagnostic evaluation when the immediate cause of acute pancreatitis is unclear.