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CEP55 as a prognostic indicator and a predictive marker in oral squamous cell carcinoma

  • 0Department of Stomatology, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
International Journal of Medical Sciences +

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May 19, 2025

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May 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

CEP55 is overexpressed in oral squamous cell carcinoma (OSCC), correlating with poor prognosis and promoting tumor growth by enhancing cell cycle progression and suppressing immune infiltration.

Area Of Science

  • Oncology
  • Molecular Biology
  • Immunology

Background

  • Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with complex pathogenesis.
  • Understanding the molecular drivers of OSCC progression is crucial for developing targeted therapies.

Purpose Of The Study

  • To investigate the role of Centrosome Protein 55 (CEP55) in the development and progression of OSCC.
  • To analyze the correlation of CEP55 expression with patient prognosis, cellular pathways, and tumor immune microenvironment.

Main Methods

  • Bioinformatic analysis of OSCC databases to assess CEP55 expression and prognostic value.
  • Immunohistochemical staining of CEP55 and cell cycle markers (PCNA, P16, P21, P53) in OSCC and adjacent tissues.
  • Gene Set Enrichment Analysis (GSEA) to identify associated biological pathways.
  • Analysis of immune cell infiltration in relation to CEP55 expression.

Main Results

  • CEP55 expression is significantly elevated in OSCC tissues compared to normal tissues, associated with poorer patient outcomes.
  • CEP55 expression positively correlates with cell cycle progression markers, suggesting a role in cell proliferation.
  • CEP55 significantly suppresses tumor immune infiltration, reducing the presence of various immune cell types while increasing a few.

Conclusions

  • CEP55 is a key driver in OSCC progression, promoting cell cycle advancement.
  • CEP55 contributes to immune evasion in OSCC by altering the tumor immune microenvironment.
  • CEP55 represents a potential therapeutic target for OSCC treatment.

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