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Anesthesia Management Using Remimazolam in A Patient With Bernard-Soulier Syndrome: A Case Report
Tomoharu Shakuo1,2, Yusuke Ishida1, Daiki Sugawara3
1Department of Anesthesiology Showa Medical University School of Medicine Tokyo Japan.
Clinical Case Reports
|May 19, 2025
Summary
This study demonstrates the safe use of remimazolam, a sedative, for anesthesia in a patient with Bernard-Soulier syndrome (BSS), a rare platelet disorder. Remimazolam showed no adverse effects on platelet function during the procedure.
Area of Science:
- Anesthesiology
- Hematology
- Pharmacology
Background:
- Bernard-Soulier syndrome (BSS) is a rare inherited platelet function disorder.
- Key features include severe thrombocytopenia and impaired platelet aggregation.
- Anesthesia management in BSS patients requires careful consideration of hemostatic risks.
Purpose of the Study:
- To evaluate the safety and efficacy of remimazolam for anesthesia in a patient with Bernard-Soulier syndrome.
- To assess the impact of remimazolam on platelet function in a BSS patient.
Main Methods:
- Case report of a patient with Bernard-Soulier syndrome undergoing a surgical procedure.
- Anesthesia was induced and maintained using remimazolam.
- Platelet function tests were monitored perioperatively.
Main Results:
- Remimazolam was successfully used for anesthesia management without complications.
- No significant adverse effects on platelet count or aggregation were observed.
- The patient experienced a smooth recovery with stable hemodynamics.
Conclusions:
- Remimazolam appears to be a safe and effective anesthetic agent for patients with Bernard-Soulier syndrome.
- This finding suggests that remimazolam may have minimal impact on platelet function in BSS.
- Further studies are warranted to confirm the safety profile of remimazolam in this patient population.
Keywords:
Bernard‐Soulier syndrome (BSS)remimazolamthrombocytopeniathromboelastographyviscoelastic testMore Related Videos
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