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PANoptosis in Sepsis: A Central Role and Emerging Therapeutic Target
Qiqi Wu1, Siyuan Qi1, Zhaofeng Kang1
1Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Abstract:
The pathogenesis of sepsis is intricately linked to regulated cell death. As a novel form of regulated cell death, PANoptosis plays a critical role in driving the inflammatory response, impairing immune cell function, and contributing to multi-organ dysfunction in sepsis. This review explores the molecular mechanisms underlying PANoptosis and its involvement in sepsis. By activating multiple pathways, PANoptosis promotes the release of inflammatory cytokines, triggering a cytokine storm that disrupts immune cell homeostasis and exacerbates organ damage. Emerging therapeutic strategies targeting PANoptosis, including chemotherapeutic agents and herbal remedies, are showing potential for clinical application. The concept of targeting PANoptosis offers a promising avenue for developing innovative treatments for sepsis.
Insights
PANoptosis, a novel cell death form, drives sepsis inflammation and organ damage. Targeting PANoptosis offers promising new sepsis treatments.
Area of Science:
- Immunology
- Cell Biology
- Pathophysiology
Background:
- Sepsis pathogenesis involves regulated cell death.
- PANoptosis is a novel regulated cell death pathway.
- PANoptosis critically influences sepsis progression.
Purpose of the Study:
- To review molecular mechanisms of PANoptosis in sepsis.
- To explore PANoptosis's role in sepsis pathogenesis.
- To discuss therapeutic strategies targeting PANoptosis.
Main Methods:
- Literature review of PANoptosis and sepsis.
- Analysis of molecular pathways involved in PANoptosis.
- Evaluation of therapeutic interventions.
Main Results:
- PANoptosis activates inflammatory cytokine release, causing a "cytokine storm."
- It impairs immune cell function and leads to multi-organ dysfunction.
- PANoptosis exacerbates sepsis-induced organ damage.
Conclusions:
- PANoptosis is a key driver of sepsis pathology.
- Targeting PANoptosis presents a promising therapeutic strategy for sepsis.
- Novel treatments for sepsis may emerge from targeting PANoptosis.
