Distribution of PAX1 and ZNF582 Hypermethylation in the Oral Exfoliated Cells of Oral Squamous Cell Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.DNA methylation of PAX1 and ZNF582 genes in oral epithelial cells shows promise for oral squamous cell carcinoma (OSCC) detection. These genes exhibit distinct methylation patterns in OSCC patients, aiding in diagnosis.
Area Of Science
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Oral squamous cell carcinoma (OSCC) detection can be improved using DNA methylation biomarkers.
- PAX1 and ZNF582 gene methylation statuses are promising candidates for OSCC detection.
Purpose Of The Study
- To investigate the distribution of PAX1 and ZNF582 gene methylation in exfoliated oral epithelial cells (OECs) from OSCC patients.
- To evaluate the potential of these methylation markers for OSCC diagnosis.
Main Methods
- Analysis of methylation data from The Cancer Genome Atlas (TCGA) and UALCAN database.
- Collection and analysis of exfoliated OECs from OSCC patients at cancerous lesion (CL), adjacent normal (AN), and contralateral normal (CN) sites.
- Evaluation of PAX1 and ZNF582 methylation levels in different oral sites.
Main Results
- Both PAX1 and ZNF582 were hypermethylated in OSCC compared to non-tumor sites.
- PAX1 showed a CL-centric methylation pattern, decreasing from CL to CN, suggesting field cancerization.
- ZNF582 methylation was significantly higher at lesion sites and showed higher sensitivity in OSCC detection, with coexistence observed in some patients.
Conclusions
- DNA methylation detection of PAX1 and ZNF582 in exfoliated OECs is valuable for OSCC diagnosis.
- Hypermethylated PAX1 and ZNF582 exhibit distinct methylation patterns within the oral cavity of OSCC patients.
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