Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Cancer Therapies02:49

Cancer Therapies

7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
Cancer Survival Analysis01:21

Cancer Survival Analysis

313
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
313
Cancer Vaccines01:30

Cancer Vaccines

310
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
310

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral contraceptive usage among healthcare workers and its impact on COVID-19 booster vaccination immunogenicity.

NPJ vaccines·2026
Same author

Correction: The BrEasT cancer afTER-CARE (BETTER-CARE) programme to improve breast cancer follow-up: design and feasibility study results of a cluster-randomised complex intervention trial.

Trials·2026
Same author

AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2026.

Breast care (Basel, Switzerland)·2026
Same author

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2026.

Breast care (Basel, Switzerland)·2026
Same author

[Post-treatment care for breast cancer].

MMW Fortschritte der Medizin·2026
Same author

AGO Breast Committee recommendations for the surgical therapy of breast cancer: Working Group on Gynecologic Cancers (AGO) update 2026.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026

Related Experiment Video

Updated: May 21, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.1K

Update Breast Cancer 2024 Part 2 - Patients with Early Stage Breast Cancer.

Wolfgang Janni1, Hans-Christian Kolberg2, Andreas D Hartkopf3

  • 1Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany.

Geburtshilfe Und Frauenheilkunde
|May 19, 2025
PubMed
Summary

New treatments for early-stage breast cancer include immune checkpoint inhibitors for triple-negative breast cancer (TNBC) and CDK4/6 inhibitors for high-risk hormone receptor-positive tumors. Biomarker research, like circulating tumor DNA (ctDNA), is also advancing treatment strategies.

Keywords:
biomarkerbreast cancerclinical studiesearly breast cancer

More Related Videos

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.4K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.2K

Related Experiment Videos

Last Updated: May 21, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.1K
Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.4K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.2K

Area of Science:

  • Oncology
  • Cancer Research
  • Translational Medicine

Background:

  • Early-stage breast cancer treatment has seen significant advancements.
  • Key developments focus on specific subtypes like triple-negative breast cancer (TNBC) and hormone receptor-positive, HER2-negative (HRpos/HER2neg) tumors with high recurrence risk.

Purpose of the Study:

  • To review recent clinical developments in early-stage breast cancer treatment.
  • To contextualize findings from recent studies with long follow-up data and translational analyses.

Main Methods:

  • Literature review of recent publications on early-stage breast cancer therapies.
  • Analysis of clinical trial data and translational research findings.

Main Results:

  • Immune checkpoint inhibitors show promise in treating TNBC.
  • CDK4/6 inhibitors are effective for HRpos/HER2neg tumors at high risk of recurrence.
  • Emerging biomarkers, including circulating tumor DNA (ctDNA), are being integrated for patient stratification and monitoring.

Conclusions:

  • Recent advancements offer improved therapeutic options for specific early-stage breast cancer subtypes.
  • Long-term follow-up data and biomarker research are crucial for refining treatment strategies and understanding patient outcomes.