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Update Breast Cancer 2024 Part 3 - Patients with Advanced Stage Breast Cancer

Diana Lüftner1, Hans-Christian Kolberg2, Andreas D Hartkopf3

  • 1Immanuel Hospital Märkische Schweiz, Buckow, Germany & Medical University of Brandenburg Theodor-Fontane, Rüdersdorf, Germany.

Geburtshilfe Und Frauenheilkunde
|May 19, 2025
PubMed

Insights

New therapies like CDK4/6 inhibitors and antibody-drug conjugates significantly improve survival for advanced breast cancer patients. This review covers recent advancements and promising treatments, offering hope for better outcomes.

Area of Science:

  • Oncology
  • Medical Therapeutics

Background:

  • Advanced stage breast cancer treatment has evolved significantly.
  • Conventional chemotherapy is being replaced by targeted therapies and immunotherapies.

Purpose of the Study:

  • To review recent advancements in the treatment of advanced stage breast cancer.
  • To summarize key findings from recent publications and conference presentations.

Main Methods:

  • Literature review of recent publications.
  • Analysis of conference presentations on breast cancer treatment.

Main Results:

  • CDK4/6 inhibitors, trastuzumab deruxtecan, and sacituzumab govitecan demonstrate significant overall survival benefits.
  • New PI3K/AKT-kinase inhibitors, SERDs, antibody-drug conjugates, immune therapies, and PARP inhibitors are emerging as promising treatments.

Conclusions:

  • The therapeutic landscape for advanced breast cancer is rapidly changing with novel agents.
  • Ongoing research and rapid study execution promise further improvements in patient survival.
Keywords:
advanced breast cancerbreast cancerclinical studiesprognosis

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