Related Experiment Video
Updated: May 21, 2025
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
D3 lymph node dissection improves perioperative outcomes and overall survival in patients with cT2N0 colorectal
Bolun Song1, Liming Wang1,2, Yinggang Chen1
1Department of Gastrointestinal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Background:
The extent of lymphadenectomy undertaken in patients with cT2N0 colorectal cancer (CRC) remains controversial. The aim of our study was to compare survival in such patients by level of lymph node dissection (LND) performed.
Methods:
This retrospective cohort study was conducted at a high-volume cancer center in Japan. Eligible patients (n=524) submitted to radical resections for cT2N0 CRC between April 2007 and December 2020 were included. Subjects were subsequently stratified by nature of LND (D2 vs. D3) and propensity score matched at 1:2 ratio. We then analyzed group rates of overall survival (OS) and relapse-free survival (RFS) before and after matching.
Results:
Before matching, the D3 (vs. D2) LND group experienced a shorter mean operative time, less intraoperative blood loss, fewer postoperative complications, and a briefer average hospital stay, showing significantly better OS (P=0.001) as well. The estimated hazard ratio (HR) was 2.0 [95% confidence interval (CI): 1.0-3.9; P=0.04]. After matching, a significant difference in OS (P=0.007) was still observed, with an estimated HR of 2.3 (95% CI: 1.0-5.1; P=0.044).
Conclusions:
D3 LND improves perioperative outcomes and OS in patients with cT2N0 CRC. Accurate preoperative imaging diagnostics are critical for proper surgical management for cT2N0 CRC.
More Related Videos
08:26Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
12:45Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022