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Updated: May 21, 2025

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Metastatic small intestinal neuroendocrine tumor presented with partial intestinal obstruction in Saudi Arabia: a
Faris Alsobyani1, Mansour Almalki1, Hassan Abu Rokbah1
1General Surgery Department, Al Noor Specialist Hospital, 3rd Ring Rd, 24241, Makkah, Saudi Arabia.
Abstract:
Well-differentiated neuroendocrine tumors (NETs) of the ileocecal region are rare but increasingly recognized gastrointestinal neoplasms. They often present vague symptoms, delaying diagnosis. Despite slow growth, these tumors can metastasize to the liver and bone, complicating management. Despite their indolent nature, these tumors can metastasize to the liver and bone, complicating treatment. We report a case of a 54-year-old woman with a one-year history of vague abdominal symptoms that worsened over the last 2 months. Contrast-enhanced computed tomography imaging revealed a mesenteric lesion leading to partial intestinal obstruction. Further imaging revealed liver and spine metastases. Colonoscopy confirmed an obstructing ileocecal mass, and biopsy identified a Grade 1 well-differentiated NET. The patient underwent laparoscopic right hemicolectomy with ileocolic anastomosis for symptom relief, followed by octreotide therapy. This case highlights the diagnostic and therapeutic challenges of metastatic ileocecal NETs and emphasizes the importance of a multidisciplinary approach for effective treatment and long-term stability.
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