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Published on: August 13, 2019
A Randomized Controlled Study on the Treatment of Isolated Interdental Intrabony Defects Using the Modified Minimally
Yuzhe Sun1, Haidong Zhang1, Churen Zhang2
1Department of Periodontology, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, China.
Aim:
This study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M-MIST) combined with a collagen-enriched bovine-derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.
Materials And Methods:
This is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M-MIST and CEBDX, and the control group received M-MIST alone. Re-evaluations were performed 1 and 2 years after surgery, with probing depth (PD) and clinical attachment level (CAL) measured at the buccal/labial and lingual/palatal sides of the defects as at baseline. Periapical radiographs and CBCT were also performed to evaluate the radiographic bone changes of the defects.
Results:
Thirty-eight defects were evaluated at the 1- and 2-year follow-ups, and both groups showed statistically significant improvements in PD, CAL and radiographic bone volume. The test group exhibited increased PD reduction (3.95 ± 1.39 mm vs. 2.95 ± 1.51 mm, p = 0.041) and CAL gain (3.58 vs. 2.53 mm on average, p = 0.043) at the buccal side of the defects. No difference was found at the lingual side. A significantly greater radiographic bone volume gain (17.77 ± 11.44 mm3 vs. 8.63 ± 7.10 mm3, p = 0.011) was found in the test group at the 2-year follow-up.
Conclusions:
M-MIST was effective both alone and with CEBDX. The addition of CEBDX significantly improved radiographic bone volume gain and PD reduction, and CAL gain at the buccal side of the defects.
