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Anti-Glycation and Anti-Aging Efficacy of Newly Synthesized Antioxidant With Autophagy Stimulating Activity
Kayoung Shin1, Yeonjae Kim1, Sungwoo Kim1,2
1Research Team, Incospharm Corp, Daejeon, South Korea.
Background:
The accumulation of advanced glycation end products (AGEs) in aged skin and their pro-aging effects suggest the potential application of anti-glycation ingredients as skin anti-aging agents.
Aims:
This study evaluated the anti-aging efficacy of a newly developed anti-glycation ingredient with antioxidant and autophagy-stimulating activities through in vitro, ex vivo, and clinical efficacy tests.
Methods:
AGEs formation in both the cell-free BSA/glyoxal system and glucose/glyoxal-treated human epidermal keratinocytes was measured, while the degradation of pre-formed BSA/AGEs by keratinocytes was assessed. Anti-glycation and anti-inflammatory effects were further examined using an ex vivo human skin explant model. Clinical anti-aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.
Results:
The tested ingredient inhibited AGE formation and accelerated the degradation of pre-formed AGEs in vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4 weeks of test product application.
Conclusion:
A newly synthesized antioxidant with autophagy-stimulating activity exhibited significant anti-glycation efficacy in both in vitro and clinical studies, suggesting its potential as an effective skin anti-aging ingredient.
Insights
This study shows a new ingredient effectively reduces advanced glycation end products (AGEs) and improves skin aging signs. It demonstrates significant anti-aging effects in vitro, ex vivo, and clinical tests for healthier skin.
Area of Science:
- Dermatology and cosmetic science
- Biochemistry of aging
- Skin physiology
Background:
- Accumulation of advanced glycation end products (AGEs) contributes to skin aging.
- Anti-glycation ingredients show potential for skin anti-aging applications.
Purpose of the Study:
- Evaluate the anti-aging efficacy of a novel anti-glycation ingredient.
- Assess antioxidant and autophagy-stimulating activities.
- Investigate efficacy through in vitro, ex vivo, and clinical studies.
Main Methods:
- Measured AGEs formation and degradation in vitro.
- Assessed anti-glycation and anti-inflammatory effects using human skin explants.
- Analyzed clinical effects on skin AGE levels, melanin, erythema, elasticity, and hydration.
Main Results:
- The ingredient inhibited AGE formation and accelerated AGE degradation in vitro.
- Reduced skin AGE levels, melanin, and erythema indices.
- Improved skin elasticity and hydration in clinical trials.
Conclusions:
- The novel antioxidant with autophagy-stimulating activity demonstrated significant anti-glycation efficacy.
- The ingredient shows potential as an effective skin anti-aging agent.
- Supported by in vitro and clinical study findings.
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