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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
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Chitosan-Polymer Conjugates as Functional Coatings for Liposomal Bioactive Delivery Systems
Trang Le1,2, Tien-Dung Nguyen-Dinh1,2, Anh-Minh Nguyen-Huu1
1Institute of Advanced Technology, Vietnam Academy of Science and Technology, 1B TL29, Thanh Loc Ward, District 12, Ho Chi Minh, 700000, Vietnam.
Chemmedchem
|May 19, 2025
Summary
This study developed polymer-coated liposomes using chitosan-polyethylene glycol-folic acid (CTS-PEG-FA) for enhanced drug delivery. These functionalized liposomes show improved cellular uptake and potent anticancer effects, offering a promising platform for drug delivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Conventional liposomes face limitations in drug delivery due to rapid clearance and poor targeting.
- Polymer-coated liposomes offer enhanced biocompatibility and targeted delivery capabilities.
- Chitosan-polyethylene glycol-folic acid (CTS-PEG-FA) conjugates present a novel approach for functionalizing liposomes.
Purpose of the Study:
- To synthesize and characterize a CTS-PEG-FA conjugate for liposome coating.
- To prepare and analyze CTS-PEG-FA-coated liposomes for drug delivery applications.
- To evaluate the drug-loading capacity, release kinetics, cellular uptake, and cytotoxicity of the developed system.
Main Methods:
- Synthesis and spectroscopic characterization of the CTS-PEG-FA conjugate.
- Preparation of liposomes using the thin-film hydration method.
- Analysis of liposome characteristics (particle size, zeta potential, morphology) and drug delivery performance (loading, release, uptake, cytotoxicity).
Main Results:
- The CTS-PEG-FA conjugate was successfully synthesized and characterized.
- CTS-PEG-FA-coated liposomes exhibited favorable particle size, zeta potential, and morphology.
- The system demonstrated enhanced cellular uptake and significant cytotoxic effects on cancer cells, with quercetin as a model drug.
Conclusions:
- CTS-PEG-FA-coated liposomes represent an efficient and versatile platform for bioactive compound delivery.
- The developed functionalized liposomes show potential for improved therapeutic performance in cancer treatment.
- This approach enhances drug delivery systems by overcoming limitations of conventional liposomes.
Keywords:
bioactive encapsulationchitosan‐polymer conjugatescontrolled releasefunctional coatingsliposomal drug deliveryMore Related Videos
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