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Tetraspanin 4 Mediates Cholesterol-Dependent Exosome Membrane Protection from Cryodamage

Rui Ji1,2, Hongli Wang1, Xia Zheng3

  • 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, P. R. China.

Nano Letters
|May 19, 2025
PubMed
Summary

Tetraspanin 4 (TSPAN4) protects exosomes from cryopreservation damage by stabilizing their membranes. Engineered TSPAN4-exosomes show improved cryoprotection, advancing exosome therapeutics.

Keywords:
cryodamage resistancecryopreservationengineered exosomesexosometetraspanin

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