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[Growth in puberty].

J R Bierich

    Padiatrie Und Padologie
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Androgenic steroids are crucial for the pubertal growth spurt, enhancing growth hormone (GH) effects and production. Without sufficient androgens, individuals like those with anorchia miss this critical growth phase.

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    Area of Science:

    • Endocrinology
    • Human Physiology
    • Pediatrics

    Background:

    • Pubertal growth velocity increases significantly, driven by androgenic steroids, primarily testosterone in males.
    • Anorchia, a condition characterized by the absence of testes, results in a missing pubertal growth spurt.
    • Androgens exert a dual role in growth regulation.

    Purpose of the Study:

    • To elucidate the role of androgenic steroids in pubertal growth.
    • To investigate the mechanisms by which androgens influence growth hormone (GH) secretion and action.

    Main Methods:

    • Observational studies in hypopituitary dwarfs treated with human growth hormone (hGH).
    • Measurements of nocturnal hGH secretion in relation to androgen levels.
    • Literature review and analysis of historical claims regarding castrates and growth.

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    Main Results:

    • Androgenic steroids potentiate the growth-stimulatory effects of hGH, essential for growth in hypogonadotrophic individuals.
    • Androgens enhance spontaneous GH production by 2-3 fold.
    • Biologically active androgens are necessary for longitudinal growth post-puberty (age 11-12).

    Conclusions:

    • Androgenic steroids are indispensable for achieving normal pubertal growth.
    • The findings challenge the notion that adult male castrates are exceptionally tall, attributing historical observations to racial differences rather than hormonal status.