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Updated: May 20, 2025

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
Published on: October 28, 2014
Alteration in Ca2+ signaling-related genes in schizophrenia
Mohammad Taheri1, Ashkan Pourtavakoli2, Vidasadat Seyyedesfahani3
1Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Background:
Calcium (Ca2+) is the most plentiful mineral in the body that partakes in various signaling pathways, such as the growth of nerve cells during the embryonic period and in the transmission of nerve messages. Aberration in Ca2+ homeostasis has been involved in the neuropsychiatric disorders.
Methods And Results:
We have investigated expression levels of SLC1A1, SLC25A12, and ATP2B2 genes from Ca2+ signaling pathway, in addition to their related lncRNAs in the blood of patients with schizophrenia. Our results revealed substantial differences in the expression of ATP2B2, SLC1A1, SLC25A12, and lnc-MTR-1:1 between cases and controls. SLC25A12 had the premier AUC value for distinction of schizophrenia patients from healthy controls. SLC1A1 ranked second in terms of AUC value.
Conclusions:
Cumulatively, we demonstrated aberrations in the expression of Ca2+-related genes in schizophrenia. These genes might be regarded as potential markers in schizophrenia.
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