Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term removal of exercise impairs flow-mediated dilation similarly in older and younger adults.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2025
Same author

Reliability of popliteal artery flow-mediated dilation in the seated position.

Physiological reports·2025
Same author

Effects of food bar chewing duration on the physiologic, metabolic, and perceptual responses to moderate-intensity running.

European journal of applied physiology·2024
Same author

Physical activity intensity and markers of inflammation in those with non-alcoholic fatty liver disease.

Diabetes research and clinical practice·2023
Same author

A single bout of breast milk expression does not increase resting metabolic rate.

American journal of human biology : the official journal of the Human Biology Council·2023
Same author

Short-term removal of exercise impairs glycemic control in older adults: A randomized trial.

Physiological reports·2023

Related Experiment Video

Updated: May 10, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.6K

Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.

Joel E Harden1, J David Branch2, Leryn J Reynolds3

  • 1Integrative Cardiometabolic Research Laboratory, School of Exercise Science, Old Dominion University, 1006C Student Recreation CTR, Norfolk, VA, 23529, USA.

Sports Medicine (Auckland, N.Z.)
|May 19, 2025
PubMed
Summary
This summary is machine-generated.

Reducing physical activity acutely impairs endothelial function, impacting vascular health. Increased inactivity duration and severity worsen these negative effects on blood vessel function.

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.2K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.4K

Related Experiment Videos

Last Updated: May 10, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

43.6K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.2K
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

17.4K

Area of Science:

  • Cardiovascular Physiology
  • Vascular Biology
  • Exercise Science

Background:

  • Endothelial dysfunction is a key factor in cardiovascular disease.
  • Reduced physical activity is linked to impaired endothelial function.
  • Diverse models of inactivity exist, necessitating a consolidated review.

Purpose of the Study:

  • To systematically review and synthesize literature on the impact of acute physical activity reduction (≤2 months) on endothelial function.
  • To provide a comprehensive understanding of how reduced activity affects vascular health.

Main Methods:

  • Systematic literature search of PubMed and Web of Science databases.
  • Inclusion of 20 appraised studies after screening by two independent reviewers.
  • Categorization of interventions into daily activity reduction, detraining, bed rest, and immobilization.

Main Results:

  • Acute physical inactivity interventions significantly reduced flow-mediated dilation in limb arteries.
  • Microvascular function in the lower limbs was also negatively affected by inactivity.
  • Interventions included reduced daily activity, detraining, bed rest, and immobilization.

Conclusions:

  • Greater duration and severity of physical inactivity interventions correlate with poorer endothelial function outcomes.
  • Future research should investigate the dose-response relationship between inactivity severity and endothelial function.
  • Acute reductions in physical activity pose a risk to vascular health.