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Updated: May 7, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Racemic Meroterpenoid with a 6/6/4/6/6/10/3 Skeleton via [2 + 2] and [4 + 2] Coupling of Sesquiterpenoid and Pyrone
Yu Zhou1,2, Xian-Gui Qiu1,2, Xing-Ren Li1
1Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Abstract:
Hypbeaone A (1), a pair of racemic meroterpenoids featuring a 6/6/4/6/6/10/3 heptacyclic core, along with its biogenic precursor, hypermonone A (2), were isolated from Hypericum beanii. Compound 1 represented the first trimeric meroterpenoid that should be biosynthesized through intermolecular [2 + 2] and [4 + 2] cycloadditions of two pyrones and one sesquiterpenoid unit. Its structure was unequivocally determined by spectroscopic analysis and X-ray crystallography. Both compounds (±)-1 and 2 exhibited potential α-glucosidase inhibitory activities.
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