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Partial Heart Transplantation: Early Experience With Pediatric Heart Valve Replacements That Grow
Neel K Prabhu1,2, Berk Aykut1,2, Michael Mensah-Mamfo1
1Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).
Abstract:
Heart valve replacement in children is fraught with long-term morbidity and mortality rates, largely because conventional implants lack the capacity to grow with the child. Partial heart transplantation presents a potential solution by transplanting only specific segments of a donor heart, thereby providing a living and growing heart valve implant. This approach harnesses the full spectrum of cardiac tissues, which, when freshly procured and supported by immunosuppression, can integrate as functional and potentially growth-capable tissue. This state-of-the-art review discusses the history and development of partial heart transplantation, its indications, recent clinical experiences, regulation, and future directions.
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