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Determinants of poor chronic obstructive pulmonary disease control
Anan S Jarab1, Walid Al-Qerem2, Karem H Alzoubi3,4
1College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
The Libyan Journal of Medicine
|May 19, 2025
Summary
Poor control in Chronic Obstructive Pulmonary Disease (COPD) is linked to older age, depression, and multiple medications. Not using long-acting muscarinic antagonists (LAMA) was associated with better COPD control.
Area of Science:
- Respiratory Medicine
- Clinical Research
Background:
- Uncontrolled Chronic Obstructive Pulmonary Disease (COPD) negatively impacts quality of life and healthcare resource utilization.
- Factors contributing to poor COPD control require further investigation.
Purpose of the Study:
- To identify factors associated with poor disease control in COPD patients.
- To explore the relationship between patient characteristics, medication, and COPD control.
Main Methods:
- Cross-sectional study involving 702 COPD patients from Jordanian outpatient respiratory clinics.
- Data collected via interviews and medical files, including medication adherence, anxiety, and depression.
- COPD severity assessed using GOLD classification; ordinal regression used for analysis.
Main Results:
- Older age, higher depression scores, and increased number of prescribed medications were significantly associated with poorer COPD control.
- Conversely, not receiving long-acting muscarinic antagonists (LAMA) was linked to better disease control.
- Majority of participants were GOLD group B (40.2%) and D (28.2%).
Conclusions:
- Depression significantly impacts COPD control, necessitating targeted mental health interventions, especially for older patients and those on multiple medications.
- Optimizing medication regimens, potentially by reconsidering LAMA use, could improve COPD management.
- Integrated care addressing both respiratory and mental health is crucial for better patient outcomes.
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