Systemic sclerosis complicating endometrial adenocarcinoma: A case report

Area of Science:

• Rheumatology
• Oncology
• Immunology

Background:

• Systemic sclerosis (SSc) is a rare autoimmune disorder.
• The simultaneous occurrence of SSc and neoplasm is exceptionally uncommon.
• This case presents a diagnostic challenge due to the rarity of this dual diagnosis.

Purpose of the Study:

• To report a rare case of co-existing Systemic Sclerosis and endometrial adenocarcinoma.
• To explore potential shared pathophysiological mechanisms between SSc and malignancy.
• To emphasize the importance of considering autoimmune diseases in patients with cancer and vice versa.

Main Methods:

• A case report of a 55-year-old female patient.
• Diagnosis of SSc based on 2013 ACR/EULAR criteria.
• Patient history included Raynaud's phenomenon and a prior diagnosis of endometrial adenocarcinoma.

Main Results:

• The patient presented with a 7-year history of digital cyanosis and Raynaud's phenomenon.
• She had a confirmed diagnosis of Federation International of Gynecology and Obstetrics stage IIIa endometrial adenocarcinoma.
• Despite discussion, the patient declined treatment and was lost to follow-up.

Conclusions:

• Persistent chronic inflammation and immune dysregulation may link the pathogenesis of SSc and cancer.
• This case underscores the complexity of managing patients with co-existing autoimmune diseases and malignancies.
• Further research is warranted to elucidate the shared mechanisms between SSc and neoplastic diseases.