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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Ankle-brachial index measurement: Skill cannot be taken for granted. Comment on Chaudru et al, p. 37-41 and Monti et al, p. 43-48.

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[Update Raynaud Phenomenon].

Ludwig Caspary1

  • 1Angiologische Praxis, Hannover, Deutschland.

Deutsche Medizinische Wochenschrift (1946)
|May 19, 2025
PubMed
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This summary is machine-generated.

Raynaud

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Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Dermatology

Background:

  • Raynaud's phenomenon (RP) is influenced by weight changes and associated with psychological conditions like depression and anxiety.
  • While RP generally has minimal socioeconomic impact, it can lead to significant disability in systemic sclerosis (SSc) patients due to severe digital complications.
  • Early identification of underlying conditions, particularly SSc, is crucial for managing RP effectively.

Purpose of the Study:

  • To review and highlight new aspects of Raynaud's phenomenon.
  • To discuss diagnostic tools and their limitations in identifying underlying causes like SSc.
  • To summarize current and emerging therapeutic strategies for severe RP, especially in the context of SSc.

Main Methods:

  • Literature review of recent studies and clinical observations concerning Raynaud's phenomenon.
  • Analysis of diagnostic modalities including capillaroscopy, antibody testing, and clinical signs.
  • Evaluation of pharmacological and non-pharmacological treatment options for RP and SSc.

Main Results:

  • Weight loss can trigger RP; depression and anxiety are frequent comorbidities.
  • Capillaroscopy is valuable for detecting SSc, but pathological findings require corroboration with antibodies and clinical signs.
  • Effective treatments for severe RP, often linked to SSc, include prostanoids, Bosentan, and potentially Botulinum-A, with autologous fat grafting as a novel approach.

Conclusions:

  • Raynaud's phenomenon has multifaceted triggers and associations, necessitating careful diagnosis.
  • Systemic sclerosis significantly increases the risk of disability in RP patients.
  • Treatment for severe RP is evolving, with ongoing research into novel therapies like stem cell grafting, while acknowledging the significant placebo effect in management.