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Updated: May 23, 2025

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain
Published on: May 14, 2014
Advances in cerebral edema research and targeted drug delivery systems
Peng Fu1, Xiu-Fen Yang1, Wen-Wen Deng1
1School of Pharmacy, Jiangsu University, Zhenjiang, China; The International Institute on Natural Products and Stem Cells (iNPS), Zhenjiang, China; Key Lab for Drug Delivery & Tissue Regeneration, Zhenjiang, China; Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Zhenjiang, China.
Abstract:
Cerebral edema, marked by excessive brain fluid accumulation, hinders stroke recovery and impacts survival, highlighting the need for effective therapies. This review examines the glymphatic system's role in post-stroke edema pathogenesis, explores edema formation mechanisms, and identifies therapeutic targets. While small molecule drugs show promise, their limited solubility and brain targeting necessitate advanced delivery approaches. Nanodrug delivery systems, capable of crossing the blood-brain barrier (BBB) and targeting cells via ligands, offer a compelling solution. We discuss the application of novel nanodrugs to enhance post-stroke edema treatment, aiming to improve survival and neurological recovery. This review seeks to guide future research in post-stroke edema management.
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