Remineralizing potential of self-assembling peptides on dentinal lesions: A systematic review of the literature

The aim of this study was to examine the efficacy of self-assembling peptides in promoting remineralization on demineralized dentin surfaces.

A comprehensive electronic search was conducted using the MEDLINE via PubMed, EMBASE, Web of Science (WOS), and Scopus databases. The inclusion criteria focused on in vitro investigations using demineralized dentin surfaces from extracted permanent human teeth. These studies applied self-assembling peptides and evaluated tissue remineralization or mechanical properties. A total of 13 manuscripts met the inclusion criteria. The PRISMA guidelines were followed, and the methodological quality and risk of bias were evaluated according to the RoBDEMAT guidelines. Additionally, tables were created for data extraction, comprising outcomes related to dentin remineralization and mechanical properties assessment.

Self-assembling peptides, particularly P11-4, have demonstrated the potential to promote remineralization and enhance the mechanical properties of demineralized dentin surfaces. Self-assembling peptides appear to be a promising approach for achieving intrafibrillar remineralization.

Dentin remineralization is one of the characteristics that biomaterials used in adhesive dentistry should aim for, as it can prolong the lifespan of restorations. Self-assembling peptides have shown potential to remineralize dentin surfaces.