ETS emerges to heat up adipose
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Updated: May 13, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
Published on: April 1, 2019
1Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Yale Center of Molecular and Systems Metabolism, Yale University School of Medicine, New Haven, Connecticut 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA matthew.rodeheffer@yale.edu.
Abstract:
In this issue of Genes & Development, Xue and colleagues (doi:10.1101/gad.352748.125) identify ETV4 as a transcription factor binding a -12 kb enhancer of UCP1 to promote chromatin accessibility, histone acetylation, and gene expression. This role for ETV4 in thermogenesis expands its known functions in adipogenesis. Importantly, these findings also highlight an emerging, broader role for E26 transformation-specific (ETS) transcription factors in adipose biology.
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