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Immunoglobulin E in aqueous humour.

J P Dernouchamps, C G Magnusson, J Michiels

    Experimental Eye Research
    |February 1, 1985
    PubMed
    Summary
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    Elevated immunoglobulin E (IgE) in aqueous humor suggests local production in various eye conditions. This finding aids in diagnosing intraocular inflammation and other serious eye diseases.

    Area of Science:

    • Ophthalmology
    • Immunology
    • Clinical Chemistry

    Background:

    • Immunoglobulin E (IgE) is crucial in allergic reactions.
    • Elevated IgE levels in ocular fluids may indicate intraocular inflammation or other pathologies.
    • Understanding IgE's role in the eye is vital for diagnosis and treatment.

    Purpose of the Study:

    • To quantify immunoglobulin E (IgE) levels in aqueous humor (AH) and serum.
    • To investigate the potential for local IgE production within the eye.
    • To correlate IgE levels with specific intraocular conditions.

    Main Methods:

    • Particle counting immunoassay used to measure IgE concentrations in AH and serum.
    • Calculation of the AH/serum IgE concentration ratio, normalized by albumin levels.

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  • Analysis of IgE levels in patients with senile cataract, uveitis, Fuchs' cyclitis, intraocular tumors, and ocular injuries.

    • Main Results:

    • Normal IgE levels in AH were below 0.75 IU ml-1 for senile cataract patients.
    • Significantly elevated IgE levels were observed in uveitis, Fuchs' cyclitis, intraocular tumors, and ocular injury.
    • An AH/serum IgE ratio greater than 0.60, indicative of local IgE synthesis, was found in 31 out of 37 examined samples.

    Conclusions:

    • Increased IgE in aqueous humor is strongly associated with intraocular inflammation and other pathological conditions.
    • The study provides evidence for local IgE production within the eye in various ocular diseases.
    • Measuring IgE in AH can be a valuable diagnostic tool for identifying intraocular inflammation.