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The prognostic role of albumin-bilirubin grade in the mortality of extrahepatic cholangiocarcinoma patients

  • 0Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Bmc Gastroenterology +

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May 19, 2025

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May 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The albumin-bilirubin (ALBI) grade, along with elevated Aspartate Aminotransferase (AST) and international normalized ratio (INR), are significant predictors of survival in patients with extrahepatic cholangiocarcinoma (eCCA). These factors can help in assessing prognosis for eCCA patients.

Area Of Science

  • Hepatobiliary surgery
  • Gastroenterology
  • Oncology

Background

  • Cholangiocarcinoma (CCA) has a poor prognosis, with liver function significantly impacting survival.
  • The albumin-bilirubin (ALBI) score is a validated tool for assessing liver function and prognosis in intrahepatic CCA (iCCA).
  • Predicting outcomes for extrahepatic CCA (eCCA) remains challenging, necessitating further investigation into prognostic markers.

Purpose Of The Study

  • To evaluate the prognostic significance of the ALBI grade in predicting overall survival for patients diagnosed with eCCA.
  • To identify key clinical and laboratory parameters that influence survival rates in eCCA patients.

Main Methods

  • A cohort of 80 eCCA patients treated at Firuzgar Hospital between 2015 and 2019 were retrospectively analyzed.
  • Patients underwent EUS-FNA or ERCP brush cytology followed by surgery; exclusion criteria ensured data integrity.
  • ALBI scores were calculated and categorized into three grades. Kaplan-Meier analysis and Cox regression models were employed to assess survival.

Main Results

  • The study included 80 eCCA patients (67.5% male, median age 67 years) with an average survival of 13.9 months.
  • 1-, 3-, and 5-year survival rates were 36.6%, 27.1%, and 15.8%, respectively.
  • ALBI grade, AST levels (>82.5 U/L), white blood cell count (>7.70 × 10⁹/L), and INR (>1.08) were identified as significant independent predictors of mortality (P < 0.05).

Conclusions

  • ALBI grade serves as a valuable prognostic factor for overall survival in eCCA patients.
  • Elevated AST levels (>82.5 U/L) and INR (>1.08) are also significant indicators of poor prognosis in eCCA.
  • These factors, including ALBI grade, can be utilized to predict survival outcomes in patients with extrahepatic cholangiocarcinoma.

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