Diastolic global longitudinal strain and acute ischemic stroke: a hidden relationship?
Melis Ozkan1, Sefa Tatar2, Osman Serhat Tokgöz1
1Department of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
BMC Cardiovascular Disorders
|May 19, 2025
Summary
Patients with acute ischemic stroke (AIS) showed higher diastolic global longitudinal strain (GLS) compared to controls. Increased GLS may indicate compensatory mechanisms for preserving brain tissue in AIS patients.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- Acute ischemic stroke (AIS) and cardiovascular system exhibit bidirectional interactions.
- Vascular risk factors significantly impact global longitudinal strain (GLS).
- Diastolic GLS may serve as a biomarker in cardiovascular and neurological conditions.
Purpose of the Study:
- To investigate the relationship between diastolic global longitudinal strain (GLS) and acute ischemic stroke (AIS).
- To evaluate GLS as a potential predictor of clinical outcomes in AIS patients.
Main Methods:
- A prospective case-control study involving 80 AIS patients and 45 controls with similar vascular risk profiles.
- Echocardiographic GLS measurements were performed within 72 hours of stroke onset.
- Demographic, clinical, and laboratory data were collected and analyzed.
Main Results:
- GLS values were significantly lower than normal in both AIS and control groups.
- AIS patients exhibited significantly higher GLS compared to controls, despite similar ejection fraction (EF).
- Increased GLS was an independent factor associated with AIS and predicted better clinical outcomes (modified Rankin Scale).
Conclusions:
- Elevated GLS in AIS patients may reflect compensatory mechanisms to preserve the penumbra.
- Diastolic GLS is a potential indicator of underlying cardiovascular adaptation in AIS.
- Further research into GLS's role in stroke pathophysiology and prognosis is warranted.
Keywords:
Acute ischemic strokeCardiac function·Ejection fractionDiastolic global longitudinal strainEchocardiographyMore Related Videos
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