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Updated: May 23, 2025

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

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Published on: May 19, 2022

Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.

Liang Cui¹, Zhen Zhang¹, Chu-Chung Huang^2,3

¹Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|May 20, 2025

Summary

This summary is machine-generated.

This study developed visual staging systems for amyloid-beta (Aβ) deposition in Alzheimer

Keywords:

Alzheimer's disease amyloid‐beta cognitive function default mode network deposition stage hippocampus neurodegeneration plasma biomarkers

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Last Updated: May 23, 2025

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Published on: May 19, 2022

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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

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Published on: April 18, 2025

Area of Science:

Neuroscience
Radiology
Biomarkers

Background:

Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposition.
Current staging systems for Aβ deposition may lack precision in early disease stages.
There is a need for refined methods to assess Aβ accumulation and its clinical correlates.

Purpose of the Study:

To develop and validate a multi-phase visual staging system for Aβ deposition in AD.
To correlate these stages with cognitive function, neurodegeneration, and blood biomarkers.
To evaluate the utility of different established staging systems (Villeneuve, Grothe, Mattsson).

Main Methods:

Utilized positron emission tomography (PET) imaging to assess Aβ deposition in 1002 participants from the Chinese Preclinical Alzheimer's Disease Study (C-PAS) cohort.
Developed three multi-phase Aβ deposition grading systems.
Acquired data through neuropsychological testing, peripheral blood biomarker collection, and multimodal neuroimaging.

Main Results:

Stage-dependent changes in cognitive function, peripheral blood biomarkers, default mode network (DMN) function, and hippocampal volumes were observed across different Aβ deposition stages.
The developed grading systems showed varying sensitivities in detecting clinical manifestations and biomarkers.
Visual methods demonstrated sensitivity in detecting early, regional Aβ deposition.

Conclusions:

Region-based multi-phase Aβ deposition staging systems are valuable for detecting early pathological changes in AD.
These systems aid in understanding disease progression and informing personalized diagnosis and intervention strategies.
The study highlights the practical utility of visual staging for early AD detection and management.