Related Experiment Video
Updated: May 21, 2025
05:52
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
14.6K
Chorea associated with systemic lupus erythematosus- a systematic review
Paulo Rogério Julio1,2, Carla Helena Capello1,2, Jaqueline Cristina de Amorim1,2
1Graduate Student at Child and Adolescent Health Program- School of Medical Science- University of Campinas, Campinas, Brazil.
Lupus
|May 20, 2025
Summary
Chorea, a movement disorder, is a rare manifestation in systemic lupus erythematosus (SLE), affecting 1.1% of patients. It often appears before or at diagnosis, particularly in childhood-onset SLE.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Chorea is a recognized neuropsychiatric manifestation of systemic lupus erythematosus (SLE).
- Understanding its prevalence and associated features is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of chorea in SLE patients.
- To identify clinical and laboratory features associated with chorea in SLE.
- To review and propose an investigation and treatment scheme for chorea in SLE.
Main Methods:
- A comprehensive literature review adhering to PRISMA guidelines.
- Searched PubMed and Scielo databases for articles published between September 1999 and January 2024.
- Included cohort studies, case series, and case reports using specific MESH terms related to chorea and SLE.
Main Results:
- Pooled prevalence of chorea in SLE patients was 1.1%.
- No association found between chorea and clinical/immunological features in cohort studies.
- In case series/reports, chorea often preceded or coincided with SLE diagnosis, especially in childhood-onset SLE.
Conclusions:
- Chorea is an infrequent manifestation in SLE.
- Factors contributing to chorea in SLE require further investigation, particularly in large cohort studies.
Related Concept Videos
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:15Parkinson's Disease: Overview
399
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
399
01:20Myasthenia Gravis: Overview and Treatment
1.0K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:15Myasthenia Gravis: Diagnostic Tests
581
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
581
01:22Lysosomal Hydrolases
3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K